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Sensitive and frequent identification of high avidity neo-epitope specific CD8+ T cells in immunotherapy-naive ovarian cancer
Sara Bobisse, Raphael Genolet, Annalisa Roberti, Janos L. Tanyi, Julien Racle, Brian J. Stevenson, Christian Iseli, Alexandra Michel, Marie-Aude Le Bitoux, Philippe Guillaume, Julien Schmidt, Valentina Bianchi, Denarda Dangaj, Craig Fenwick, Laurent Derré
Nature Communications
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
Rajani Ravi, Kimberly A. Noonan, Vui Pham, Rishi Bedi, Alex Zhavoronkov, Ivan V. Ozerov, Eugene Makarev, Artem V. Artemov, Piotr T. Wysocki, Ranee Mehra, Sridhar Nimmagadda, Luigi Marchionni, David Sidransky, Ivan M. Borrello, Evgeny Izumchenko & Atul Bed
Nature Communications
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
Ben O’Leary, Sarah Hrebien, James P. Morden, Matthew Beaney, Charlotte Fribbens, Xin Huang, Yuan Liu, Cynthia Huang Bartlett, Maria Koehler, Massimo Cristofanilli, Isaac Garcia-Murillas, Judith M. Bliss & Nicholas C. Turner
Nature Communications
Heritable DNA methylation marks associated with susceptibility to breast cancer
Jihoon E. Joo, James G. Dowty, Roger L. Milne, Ee Ming Wong, Pierre-Antoine Dugué, Dallas English, John L. Hopper, David E. Goldgar, Graham G. Giles, Melissa C. Southey, et al.
Nature Communications
Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
Alexei F. Kirkin, Karine N. Dzhandzhugazyan, Per Guldberg, Johnny Jon Fang, Rikke S. Andersen, Christina Dahl, Jann Mortensen, Tim Lundby, Aase Wagner, Ian Law, Helle Broholm, Line Madsen, Christer Lundell-Ek, Morten F. Gjerstorff, Henrik J. Ditzel, Marti
Nature Communications
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
Julie George, Vonn Walter, […], Roman K. Thomas
Nature Communications
Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer
Jin Sheng, Wenfeng Fang, Juan Yu, Nan Chen, Jianhua Zhan, Yuxiang Ma, Yunpeng Yang, Yan Huang, Hongyun Zhao & Li Zhang
Scientific Reports
Characterization of different CTC subpopulations in non-small cell lung cancer
Annkathrin Hanssen, Jenny Wagner, Tobias M. Gorges, Aline Taenzer, Faik G. Uzunoglu, Christiane Driemel, Nikolas H. Stoecklein, Wolfram T. Knoefel, Sebastian Angenendt, Siegfried Hauch, Djordje Atanackovic, Sonja Loges, Sabine Riethdorf, Klaus Pantel & Ha
Scientific Reports
Patterns of metastasis in colon and rectal cancer
Matias Riihimäki, Akseli Hemminki, Jan Sundquist & Kari Hemminki
Scientific Reports
Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers
Aritro Nath & Christina Chan
Scientific Reports
A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis
Ai Takemoto, Mina Okitaka, Satoshi Takagi, Miho Takami, Shigeo Sato, Makoto Nishio, Sakae Okumura & Naoya Fujita
Scientific Reports
Improved detection of circulating tumor cells in non-metastatic high-risk prostate cancer patients
Andra Kuske, Tobias M. Gorges, Pierre Tennstedt, Anne-Kathrin Tiebel, Raisa Pompe, Felix Preißer, Sandra Prues, Martine Mazel, Athina Markou, Evi Lianidou, Sven Peine, Catherine Alix-Panabières, Sabine Riethdorf, Burkhard Beyer, Thorsten Schlomm & Klaus P
Scientific Reports
Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer
Dong-Xu He, Feng Gu, Fei Gao, Jun-jun Hao, Desheng Gong, Xiao-Ting Gu, Ai-Qin Mao, Jian Jin, Li Fu & Xin Ma
Scientific Reports
Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis
Yao Wang, Rohit Ramakant Jadhav, Joseph Liu, Desiree Wilson, Yidong Chen, Ian M. Thompson, Dean A. Troyer, Javier Hernandez, Huidong Shi, Robin J. Leach, Tim H.-M. Huang & Victor X. Jin
Scientific Reports
Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
Arutha Kulasinghe, Thao Huynh Phuoc Tran, Tony Blick, Ken O’Byrne, Erik W. Thompson, Majid E. Warkiani, Colleen Nelson, Liz Kenny & Chamindie Punyadeera
Scientific Reports
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma
Sonia Coni, Anna Barbara Mancuso, Laura Di Magno, Giulia Sdruscia, Simona Manni, Silvia Maria Serrao, Dante Rotili, Eleonora Spiombi, Francesca Bufalieri, Marialaura Petroni, Monika Kusio-Kobialka, Enrico De Smaele, Elisabetta Ferretti, Carlo Capalbo, Ant
Scientific Reports
Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia
Chang-Sook Hong, Priyanka Sharma, Saigopalakrishna S. Yerneni, Patricia Simms, Edwin K. Jackson, Theresa L. Whiteside & Michael Boyiadzis
Scientific Reports
Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer
K. M. Patel, K. E. van der Vos, C. G. Smith, F. Mouliere, D. Tsui, J. Morris, D. Chandrananda, F. Marass, D. van den Broek, D. E. Neal, V. J. Gnanapragasam, T. Forshew, B. W. van Rhijn, C. E. Massie, N. Rosenfeld & M. S. van der Heijden
Scientific Reports
Evidence for Treatment-by-Biomarker interaction for FDA-approved Oncology Drugs with Required Pharmacogenomic Biomarker Testing
Alexandre Vivot, Isabelle Boutron, Geoffroy Béraud-Chaulet, Jean-David Zeitoun, Philippe Ravaud & Raphaël Porcher
Scientific Reports
Catch and Release: rare cell analysis from a functionalised medical wire
Shukun Chen, Amin El-Heliebi, Gerlinde Tauber, Tanja Langsenlehner, Michaela Pötscher, Karl Kashofer, Zbigniew T. Czyż, Bernhard Polzer, Sabine Riethdorf, Andra Kuske, Gerd Leitinger, Klaus Pantel, Thomas Kroneis & Peter Sedlmayr
Scientific Reports
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach
Rahul Metri, Abhilash Mohan, Jérémie Nsengimana, Joanna Pozniak, Carmen Molina-Paris, Julia Newton-Bishop, David Bishop & Nagasuma Chandra
Scientific Reports
Evaluation of serum epidermal growth factor receptor (EGFR) in correlation to circulating tumor cells in patients with metastatic breast cancer
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter A. Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm & Volkmar Müller
Scientific Reports
Combined immunotherapy with anti-PDL-1/PD-1 and anti-CD4 antibodies cures syngeneic disseminated neuroblastoma
Valentina Rigo, Laura Emionite, Antonio Daga, Simonetta Astigiano, Maria Valeria Corrias, Concetta Quintarelli, Franco Locatelli, Silvano Ferrini & Michela Croce
Scientific Reports
LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis
Juozas Kupcinskas, Ruta Steponaitiene, Cosima Langner, Giedre Smailyte, Jurgita Skieceviciene, Limas Kupcinskas, Peter Malfertheiner & Alexander Link
Scientific Reports
Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors
Aubrey L. Miller, Patrick L. Garcia, Joseph G. Pressey, Elizabeth A. Beierle, David R. Kelly, David K. Crossman, Leona N. Council, Richard Daniel, Raymond G. Watts, Stuart L. Cramer & Karina J. Yoon
Scientific Reports
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